When figuring out what drivers or third-party software may be causing trouble
In Safe Mode, the majority of device drivers do not load. This means if the printer or scanner is causing an issue, it can be identified as such when the computer is in Safe Mode. The same goes for figuring out the issue with third-party software.
This could just be an issue of a new game or application recently causing problems. Removing the program and seeing if it makes any changes could save a lot of money and time.
Your computer can seem to be working perfectly one day, but then becomes non-functional. If that is the case, going with a System Restore can allow you to go back to a point when the computer was functioning. From Safe Mode, you can step back in time to a system status when everything was stable. System Restore will show a few restore points, or system snapshots, you can select and go from there. It might be the fix that is needed if there is something new that is causing problems.
Identifying a corrupted registry
There are scenarios where a registry might seem completely corrupted, and a new installation of Windows is one of the only solutions. While it is frustrating to have to deal with something like that, having a computer in Safe Mode helps identify the problem. System Mechanic® has a feature that can also help identify and fix registry issues.